Selected Publications

Awards & Honors

  • 2025 22th National Innovation Award (二十二屆國家新創獎)
  • 2025 Poster session, Multiomics and Precision Medicine Joint Conference (MOPM)
  • 2025 Funding initiative, TMU x UAAT/Tohoku University/University of Cagliari International Collaboration
  • 2025 Certificate of completion, TMUH Quality Management Innovation Workshop (醫品工作坊)
  • 2025 Modulator, Prostate Cancer International Symposium (PCIS25)
  • 2025 Guest editor, Journal of Visualized Experiments (JoVE)
  • 2023 Poster session, Polyploidy Across the Tree of Life
  • 2023 Poster session, American Association for Cancer Research (AACR)
  • 2021-2023 New Partnership Program for the connection to the Top Labs in the World
  • 2020 Postgraduate Outstanding and Academic Research Award in National Taiwan medical College
  • 2019-2021 Higher Education Sprout Project
  • 2019 Excellent Oral Presentation Award in Jun-Yaw Lin Science and Education Foundation
  • 2019 Scholarship in memory of Madam Mian Hsieh
  • 2017 Poster session, American Association for Cancer Research (AACR)
  • 2015-2018 New Partnership Program for the connection to the Top Labs in the World
  • 2015, Taiwan Rotary Academic Scholarship
  • 2014, Scholarship in LungYen Foundation
  • 2013, Scholarship in LungYen Foundation

Research Grants

  • 2026-2029 衛服部癌症轉譯研究計畫
  • 2026 臺灣大學醫學院附設醫院暨臺北醫學大學合作計畫
  • 2025 TMU SPARK Program
  • 2025 TMU pre-SPARK Program
  • 2025 臺灣大學醫學院附設醫院暨臺北醫學大學合作計畫
  • 2024-2026 國科會新進人員計畫
  • 2024臺北醫學大學新進人員計畫

Publications

  1. Metabolomics-Based Liquid Biopsy for Predicting Clinically Significant Prostate Cancer. Yuan-Chi Lin, Chung-Hsin Chen, Ming-Shyue Lee, Cheng-Fan Lee, Pei-Wen Hsiao, Hsiang-Po Huang, Yeong-Shiau Pu, Cancers, November 28, 2025

  2. Dual prophylactic and therapeutic potential of iPSC-based vaccines and neoantigen discovery in colorectal cancer. Si-Han Jwo, Shang-Kok Ng, Chin-Tzu Li, Shao-Peng Chen, Li-Yu Chen, Pin-Jung Liu, Huai-Jie Wang, Jr-Shiuan Lin, Chun-Jung Ko, Cheng-Fan Lee, Chun-Hao Wang, Xiaoming Ouyang, Lin Wang, Tzu-Tang Wei, Theranostics, April 28, 2025

  3. The involvement of Cyclin-Dependent Kinase 7 (CDK7) and 9 (CDK9) in coordinating transcription and cell cycle checkpoint regulation. Cheng-Fan Lee*, Kenneth J. Pienta, Sarah R. Amend, Cell Cycle, April 4, 2025

  4. Predicting clinically significant prostate cancer using urine metabolomics via liquid chromatography mass spectrometry. Chung-Hsin Chen, Hsiang-Po Huang, Kai-Hsiung Chang, Ming-Shyue Lee, Cheng-Fan Lee, Chih-Yu Lin, Yuan Chi Lin, William J Huang, Chun-Hou Liao, Chih-Chin Yu, Shiu-Dong Chung, Yao-Chou Tsai, Chia-Chang Wu, Chen-Hsun Ho, Pei-Wen Hsiao, Yeong-Shiau Pu, The World Journal of Men’s Health, Jan 2, 2024

  5. Prediction of clinically significant prostate cancer through urine metabolomic signatures: A large-scale validated study. Hsiang-Po Huang, Chung-Hsin Chen, Kai-Hsiung Chang, Ming-Shyue Lee, Cheng-Fan Lee, Yen-Hsiang Chao, Shih-Yu Lu, Tzu-Fan Wu, Sung-Tzu Liang, Chih-Yu Lin, Yuan Chi Lin, Shih-Ping Liu, Yu-Chuan Lu, Chia-Tung Shun, William J. Huang, Tzu-Ping Lin, Ming-Hsuan Ku, Hsiao-Jen Chung, Yen-Hwa Chang, Chun-Hou Liao, Chih-Chin Yu, Shiu-Dong Chung, Yao-Chou Tsai, Chia-Chang Wu, …Yeong-Shiau Pu., Journal of Translational Medicine, Oct 11, 2023.

  6. Novel urinary tract obstruction marker discovery by multi-marker profiling of urinary extracellular vesicles derived from a rat UTO model. Nora M Haney, Chi-Ju Kim, Morgan D Kuczler, Cheng-Fan Lee, Kara Lombardo, Trinity J Bivalacqua, Kenneth J Pienta, Sarah R Amend. Am J Clin Exp Urol, April 15, 2023.

  7. Nuclear morphology and functional characteristics that enable survival of cells in the polyaneuploid cancer cell state following cytotoxic chemotherapy. Chi-Ju Kim, Anna LK Gonye, Kevin Truskowski, Cheng-Fan Lee, Kenneth J Pienta, Sarah R Amend. Neoplasia, September 19, 2022.

  8. Split-hand Index for Amyotrophic Lateral Sclerosis Diagnosis: A Frequentist and Bayesian Meta-analysis. Wei-Zhen Lu, Hui-An Lin, Sen-Kuang Hou, Cheng-Fan Lee, Chyi-Huey Bai, Sheng-Feng Lin. Clinical Neurophysiology, Augest, 2022.

  9. Matriptase-2/NR4A3 axis switches TGF-β action toward suppression of prostate cancer cell invasion, tumor growth, and metastasis. Hsin-Ying Lin, Chun-Jung Ko, Tzu-Yu Lo, Shang-Ru Wu, Shao-Wei Lan, Chen-An Huang, Yi-Chin Lin, Hsin-Hsien Lin, Hsin-Fang Tu, Cheng-Fan Lee, Pei-Wen Hsiao, Hsiang-Po Huang, Mei-Jou Chen, Kai-Hsiung Chang, Ming-Shyue Lee. Oncogene, May, 2022.

  10. The central role of Sphingosine kinase 1 in the development of neuroendocrine prostate cancer (NEPC): A new targeted therapy of NEPC. Cheng-Fan Lee, Yu‐An Chen, Elizabeth Hernandez, Rey‐Chen Pong, Shihong Ma, Mia Hofstad, Payal Kapur, Haiyen Zhau, Leland WK Chung, Chih‐Ho Lai, Ho Lin, Ming‐Shyue Lee, Ganesh V Raj, Jer‐Tsong Hsieh. Clin Transl Med., Feb, 2022.

  11. Afatinib exerts immunomodulatory effects by targeting the pyrimidine biosynthesis enzyme CAD. Hsin-Fang Tu, Chun-Jung Ko, Ching-Tai Lee, Cheng-Fan Lee, Shao-Wei Lan, Hsin-Hsien Lin, Hsin-Ying Lin, Chia-Chi Ku, Der-Yen Lee, I-Chun Chen, Ya-Hui Chuang, Francisco Del Caño-Ochoa, Santiago Ramón-Maiques, Chao-Chi Ho, Ming-Shyue Lee, Geen-Dong Chang, Cancer Res, Jun, 2021.

  12. SPARC is a key mediator of TGF‐β‐induced renal cancer metastasis. Ji‐Ming Bao, Qiang Dang, Chun‐Jung Lin, U‐Ging Lo, Boris Feldkoren, Andrew Dang, Elizabeth Hernandez, Fei Li, Vandana Panwar, Cheng-Fan Lee, Jun‐Jie Cen, Bing Guan, Vitaly Margulis, Payal Kapur, Rolf A Brekken, Jun‐Hang Luo, Jer‐Tsong Hsieh, Wan‐Long Tan, Journal of cellular physiology, March, 2021.

  13. Gain-of- “endocytic’function in mutant p53 cancer cells. Ashley M Lakoduk, Cheng-Fan Lee, Ping-Hung Chen, JBC, Dec, 2020.

  14. Inhibition of TMPRSS2 by HAI-2 reduces prostate cancer cell invasion and metastasis. Chun-Jung Ko, Ting-Wei Hsu, Shang-Ru Wu, Shao-Wei Lan, Ting-Feng Hsiao, Hsin-Ying Lin, Hsin-Hsien Lin, Hsin-Fang Tu, Cheng-Fan Lee, Cheng-Chung Huang, Mei-Ju May Chen, Pei-Wen Hsiao, Hsiang-Po Huang, Ming-Shyue Lee, Oncogene, May, 2020.

  15. Activation of sphingosine kinase by lipopolysaccharide promotes prostate cancer cell invasion and metastasis via SphK1/S1PR4/matriptase. Lee CF, Dang A, Hernandez E, Pong RC, Chen B, Sonavane R, Raj G, Kapur P, Lin HY, Wu SR, Ko CJ, Lo UG, Lee HY, Hsieh JT, Lee MS, Oncogene, Jul;38(28):5580-5598, 2019.

  16. The Role and Mechanism of Epithelial-to-Mesenchymal Transition in Prostate Cancer Progression, U-Ging Lo, Cheng-Fan Lee, Ming-Shyue Lee, Jer-Tsong Hsieh, IJMS, Sep 30;18(10), 2017.

  17. Targeting annexin A2 reduces tumorigensis and therapeutic resistance of nasopharyngeal carcinoma, Chen CY, Lin YS, Chen CL, Chao PZ, Chiou JF, Kuo CC, Lee FP, Lin YF, Sung YH, Lin YT, Lee CF, Chen YJ, Chen CH, Oncotarget, Sep 29;6(29):26946-59, 2015.

  18. Huntingtin-Associated Protein 1 Interacts with Breakpoint Cluster Region Protein to Regulate Differentiation, Huang PT, Chen CH, Hsu IU, Salim SA, Kao SH, Cheng CW, Lai CH, Lee CF, Lin YF, Plos one, 10(2): e0116372. 2015.